The original Ketogenic Diet that was designed in 1923 by Dr. Russell Wilder at the Mayo Clinic for the treatment of epilepsy.

With a 4:1 ratio of fat to protein and carbs, 90% of calories come from fat, 6% from protein, and 4% from carb. Although a 4:1 ratio is considered the gold-standard for a Ketogenic diet, a 3:1 ratio is also included in descriptions of Ketogenic Diet in many publications.

The Ketogenic Diet is an individualized and structured diet that provides specific meal plans. Foods are weighed in grams and meals are designed to be consumed in their entirety to reach desired results.

The ratio of this diet can be increased for a more therapeutic outcome, and also lowered for better tolerance. This diet is also considered a low glycemic therapy and results in steady glucose and insulin levels.

 

A High Carb diet is not ketogenic, so why does some people using such a diet get a high response?

The Ketonix sensor is sensitive to acetone, methane and alcohol. For someone using a ketogenic/low-carb diet the response is from the acetone. Some people that use a High Carb diet could produce a high response, but from methane. The methane comes from bacterias in the small intestine. A healthy gut with bacterias in the right place, does not produce methane by breath. The condition is called SIBO, Small Intesinal Bacteria Overgrowth. It's defined as the presence of excessive bacteria in the small intestine.

The influence of the methane from the bacterias is small, if any, when using a low carb diet.

If you are using a high carb diet, we suggest testing in the morning before any food or drink (except a glas of cold water).

Dukowicz, A. C., Lacy, B. E., & Levine, G. M. (2007). Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterology & hepatology3(2), 112–122.

 



 

When Fat is metabolized into ketone energy (acetoacetate), breath ketones are released (acetone). The more fat that is used to create ketones, the more breath ketones are relased.
When your cells need ketone energy, all acetoacetate is used (except for what was turned into acetone). Neither urine or blood ketones are formed in this context.

 

 

 

When your cell nergy need decrease, the excess acetoacetate have two fates: 1) when cells are not adapted, it leaves body in the urine. 2) when cells are adapted, some acetoacetate could be saved for later, when ketone energy is needed again.

In other words, when there is any breakdown of fat into ketone energy, breath ketones are released. When the need for ketone energy decrease, the excess ketone molecules will be disposed in urine or packaged into a more stable molecule (beta-hydroxybutyrate) which can circulate in blood until ketone energy is needed again. Urine and Blood Ketones are present when ketosis decrease. 

For healthy people, measuring blood ketones does not mean much, it could be nothing and you still be ini ketosis but your cells need all ketone energy it can get. It could be high from accumulating over a period or just zero because your have not been in Ketosis in a while.

Blood Ketones are only a valid measure for people with type 1 diabetes or type 2 taking SGLT2 inhibitors (also called gliflozins) medicatio, as the Blood ketones can not be converted back to acetoacetate when blood glucose is high.

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